Primed for
breakthrough

We have cultivated a rapidly growing pipeline, with each molecule offering specific and distinct benefits that can be collectively used to cover a range of chronic inflammatory diseases. Our portfolio of differentiated candidates delivers advances in potency, tissue/brain penetration and chemical structural diversity.

Program
Program
Discovery
Discovery
IND-enabling
IND-enabling
Phase 1
P1
Phase 2
P2
NT-0796
Obesity
Cardiovascular Risk
Our lead molecule derived from our proprietary chemistry that is unlike any other NLRP3 inflammasome inhibitor in the space. NT-0796 is designed to deliver an intracellular payload directly to the specific immune cell types that drive inflammatory diseases. Development of NT-0796 is now progressing in a Phase II study in Participants With Obesity With or Without Type 2 Diabetes. NT-0796 is being evaluated both as a monotherapy (NCT07055516) and in combination with semaglutide (NCT07220629).

In 2024, we completed the Phase 1b/2a randomized, double-blind placebo-controlled study to assessing the effect of NT-0796 on inflammation in obese participants at risk of cardiovascular disease (NCT06129409). Read our press release for more information.
NT-0249
NT-0249 is a brain-penetrant NLRP3 inflammasome inhibitor with excellent potency and optimized development characteristics, allowing us to develop a low-dose therapy with the potential to address chronic inflammatory diseases of the body. NT-0249 a Phase II-ready asset available for partnering.
NT-0150
This Phase I-ready compound is uniquely designed from a novel chemotype as a fully brain-penetrant NLRP3 inflammasome inhibitor, with the potential to treat a broad range of neuroinflammatory and neurodegenerative diseases.
Additional Peripheral/
Neuro Development Candidates
3D render of human body with orange dots pointing to major organs and related disorders associated with NLRP3 inflammasome activation.
3D render of human body with orange dots pointing to major organs and related disorders associated with NLRP3 inflammasome activation.
Cardiovascular Study Infographic
Cardiovascular Study Infographic

For more details, read our press release.